Department of Biochemistry and Molecular Biology

Wei Huang

Associate Professor / Master's supervisor | Department：Department of Biochemistry and Molecular Biology

Email：weihuang@ccmu.edu.cn

010-83950522 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area： Dr. Huang studies the epigenetic regulatory mechanisms of tumorigenesis, metastasis and drug resistance, focuses on the molecular mechanisms of histone-modifying enzymes, transcription factors on the transcriptional regulation process during the breast cancer progression.

Education
2012-2018: Ph.D. in Medical Biochemistry and Molecular Biology, Tianjin Medical University, China
2007-2012: B.S. in Medical Laboratory Science, Tianjin Medical University, China

Work Experience
2022-present: Associate Professor, School of Basic Medical Sciences, Capital Medical University, China
2018-2021: Lecturer, School of Basic Medical Sciences, Capital Medical University, China

*：Co-first author; #：Co-corresponding author

1.Dandan Feng*, Jie Gao*, Ruiqiong Liu*, Wei Liu, Tianyang Gao, Yunkai Yang, Die Zhang, Tianshu Yang, Xin Yin, Hefen Yu, Wei Huang#, Yan Wang#. CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A. Protein & Cell,2024, 15(10), 744-765. DOI: 10.1093/procel/pwae010.

2.Jingyao Zhang, Yinuo Wang, Jingjing Zhang, Xin Wang, Jiaxiang Liu, Miaomiao Huo, Ting Hu, Tianyu Ma, Die Zhang, Yu Li, Chang Guo, Yunkai Yang, Min Zhang, Baowen Yuan, Hao Qin, Xu Teng, Tianyang Gao, Xinhui Hao, Hefen Yu, Wei Huang#, Binghe Xu#, Yan Wang#. The feedback loop between MTA1 and MTA3/TRIM21 modulates stemness of breast cancer in response to estrogen. Cell Death & Disease, 2024,15(8), 597. DOI: 10.1038/s41419-024-06942-w.

3.Min Zhang*, Ting Hu*, Tianyu Ma*, Wei Huang#, Yan Wang#. Epigenetics and environmental health. Frontiers of Medicine, 2024, 18(4), 571-596. DOI: 10.1007/s11684-023-1038-2.

4.Tianyang Gao, Xinhui Hao, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyu Ma, Hefen Yu, Xu Teng, Yong Wang, Yunkai Yang#, Wei Huang#, Yan Wang#. Transcription factor ZEB1 coordinating with NuRD complex to promote oncogenesis through glycolysis in colorectal cancer. Frontiers in Pharmacology, 2024, 15, 1435269. DOI: 10.3389/fphar.2024.1435269.

5.Wei Liu*, Yi Zeng*, Xinhui Hao, Xin Wang, Jiaxiang Liu, Tianyang Gao, Mengdi Wang, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyu Ma, Die Zhang, Xu Teng, Hefen Yu, Min Zhang, Baowen Yuan, Wei Huang#, Yunkai Yang#, Yan Wang#. JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte-derived leptin. Cancer Communications, 2023, 43(10), 1117-1142. DOI: 10.1002/cac2.12479.

6.Xin Yin, Xu Teng, Tianyu Ma, Tianshu Yang, Jingyao Zhang, Miaomiao Huo, Wei Liu, Yunkai Yang, Baowen Yuan, Hefen Yu, Wei Huang#, Yan Wang#. RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis. Cell Death & Differentiation, 2022, 29(11), 2203-2217. DOI: 10.1038/s41418-022-01010-2.

7.Xu Teng*, Tianshu Yang*, Baowen Yuan*, Yunkai Yang*, Jiaxiang Liu, Xin Wang, Yong Wang, Tianyu Ma, Xin Yin, Hefen Yu, Shuang Wang, Wei Huang. Prognostic analysis of patients with breast cancer based on tumor mutational burden and DNA damage repair genes. Frontiers in Oncology, 2023, 13, 1177133. DOI: 10.3389/fonc.2023.1177133.

8.Wei Huang, Jingyao Zhang, Miaomiao Huo, Jie Gao, Tianshu Yang, Xin Yin, Pei Wang, Shuai Leng, Dandan Feng, Yang Chen, Yang Yang, Yan Wang. CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway. Advanced Science, 2021, 8(10), 2001515. DOI: 10.1002/advs.202001515.

9.Yang Yang*, Wei Huang*, Rongfang Qiu, Ruiqiong Liu, Yi Zeng, Jie Gao, Yu Zheng, Yongqiang Hou, Shuang Wang, Wenqian Yu, Shuai Leng, Dandan Feng, and Yan Wang. LSD1 Coordinates with the SIN3A/HDAC Complex and Maintains Sensitivity to Chemotherapy in Breast Cancer. Journal of Molecular Cell Biology, 2018, 10(4), 285-301. DOI: 10.1093/jmcb/mjy021.

10.Tianshu Yang, Wei Huang, Tianyu Ma, Xin Yin, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyang Gao, Wei Liu, Die Zhang, Hefen Yu, Xu Teng, Min Zhang, Hao Qin, Yunkai Yang, Baowen Yuan, and Yan Wang. The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis. Advanced Science, 2023, 10(14), 202202737. DOI: 10.1002/advs.202202737.