Department of Cell Biology

Le Yang

Associate Professor/Master Supervisor | Department：Department of Cell Biology

Email：yangle@ccmu.edu.cn

010-83950469 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：The Yang laboratory studies the mechanism of liver injury repair, focused on studying the key collagen modifying enzymes and their working mechanisms in liver fibrosis regression.

Education
2007-2012: Ph.D. in Cell Biology, School of Basic Medical Sciences, Capital Medical University, China
2003-2007: B.S. in Biotechnology, College of Life Science, Central University for Nationalities, China

Work Experience
2019-present: Associate Professor, School of Basic Medical Sciences, Capital Medical University, China
2012-2018: Lecturer, School of Basic Medical Sciences, Capital Medical University, China

*：Co-first author; #：Co-corresponding author

1.Wenhui Yue, Hang Zhang, Yue Gao, Jingru Ding, Renmin Xue, Chengbin Dong, Fuquan Liu, Lin Yang, Le Yang#, Liying Li#. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2024 May 1;1870(5):167205.

2.Le Yang*, Hang Zhang*, Chengbin Dong, Wenhui Yue, Renmin Xue, Fuquan Liu, Lin Yang and Liying Li. Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast. Int J Mol Sci. 2023 Jan 7;24(2):1177.

3.Le Yang, Wenhui Yue, Hang Zhang, Zhi Zhang, Renmin Xue, Chengbin Dong, Fuquan Liu, Na Chang, Lin Yang, Liying Li. Dual targeting of angipoietin-1 and von willebrand factor by microRNA-671-5p attenuates liver angiogenesis and fibrosis. Hepatol Commun. 2022 Jun;6(6):1425-1442.

4.Le Yang*, Wenhui Yue*, Hang Zhang, Yue Gao, Lin Yang, Liying Li. The role of roof plate-specific spondins in liver homeostasis and disease. Liver Res. 2022 Sep;6(3):139-145.

5.Le Yang*, Lei Tian*, Zhi Zhang*, Xuan Zhou, Xiaofang Ji, Fuquan Liu, Chengbin Dong, Lei Hou, Xinhao Zhao, Na Chang, Lin Yang, Liying Li. Cannabinoid receptor 1/miR-30b-5p axis governs macrophage NLRP3 expression and inflammasome activation in liver inflammatory disease. Mol Ther Nucleic Acids. 2020 Jun 5; 20: 725-738.

6.Xiaofang Ji*, Le Yang*, Zhi Zhang, Kai Zhang, Na Chang, Xuan Zhou, Lei Hou, Lin Yang, Liying Li. Sphingosine 1-phosphate/microRNA-1249-5p/monocyte chemotactic protein-1 axis involves in macrophage-associated inflammation in fatty liver injury. Eur J Immunol. 2020 Nov;50(11):1746-1756.

7.Le Yang*, Chengbin Dong*, Jingjing Yang, Lin Yang, Na Chang, Changbo Qi, Liying Li. MicroRNA-26b-5p inhibits mouse liver fibrogenesis and angiogenesis by targeting PDGF receptor-beta. Mol Ther Nucleic Acids. 2019 Feb 26;16:206-217.

8.Le Yang*, Chengbin Dong, Lei Tian, Xiaofang Ji, Lin Yang, Liying Li. Gadolinium chloride restores the function of the gap junctional intercellular communication between hepatocytes in a liver injury. Int J Mol Sci. 2019 Jul 31;20(15):3748.

9.Le Yang*, Shi Yue*, Lin Yang, Xin Liu, Zhen Han, Yuanyuan Zhang, Liying Li. Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. J Hepatol. 2013 Jul;59(1):114-23.

10.Le Yang, Na Chang, Xin Liu, Zhen Han, Tieping Zhu, Changyong Li, Lin Yang, Liying Li. Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-b1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptors axis. Am J Pathol. 2012;181:85-97.