1. Du X, Wang H, Liu S, Song Y, Chen X, Chen Z, Zhou R, Du J, Zhang W, Gao R, Li H, Zhang G, Mao X, Chang L#, Wu Y#. Astrocytic GluN2A alleviates sleep deprivation-induced elevation of Aβ through regulating neprilysin and AQP4 via the calcineurin/NFAT pathway. Prog Neurobiol. 2025 May; 248:102744. DOI: 10.1016/j.pneurobio.2025.102744.
2. Chen X, Hu G, Chang L, Li X, Tang Y, Wu Y, Zhang R, Zhang C, Wang J, Wang X, Wang S. Nitrate ameliorates myelin loss and cognitive impairment in Alzheimer's disease through upregulation of neuronal sialin and subsequent inhibition of TPPP phosphorylation. Sci Bull (Beijing). 2025 Apr 30;70(8):1224-1229. DOI: 10.1016/j.scib.2025.03.017.
3. Fan X*, Mao X*, Yu P, Han D, Chen C, Wang H, Zhang X, Liu S, Chen W, Chen Z, Du X, Jin L, Song Y, Li H, Zhang N, Wu Y#, Chang L#, Wang C#. Sleep disturbance impaired memory consolidation via lateralized disruption of metabolite in the thalamus and hippocampus: A cross-sectional proton magnetic resonance spectroscopy study. J Alzheimers Dis. 2024 Dec;102(4):1057-1073. DOI: 10.1177/13872877241295401.
4. Liu S, Du X, Chen Z, Zhou R, Wang H, Mao X, Du J, Zhang G, Li H, Song Y, Chang L#, Wu Y#. Activation of astrocytic NMDA receptors counteracted Aβ-induced reduction of BDNF and elevation of GFAP and complement 3 in the hippocampal astrocytes. Neuroscience. 2024 Nov 1;559:303-315. DOI: 10.1016/j.neuroscience.2024.09.019.
5. Wang H*, Li J, Tu W, Wang Z, Zhang Y, Chang L#, Wu Y#, Zhang X#*. Identification of Blood Biomarkers Related to Energy Metabolism and Construction of Diagnostic Prediction Model Based on Three Independent Alzheimer's Disease Cohorts. J Alzheimers Dis. 2024;100(4):1261-1287. DOI: 10.3233/JAD-240301.
6. Mao X, Han D, Guo W, Zhang W, Wang H, Zhang G, Zhang N, Jin L, Nie B, Li H, Song Y, Wu Y#, Chang L#. Lateralized brunt of sleep deprivation on white matter injury in a rat model of Alzheimer's disease. Geroscience. 2024 Apr;46(2):2295-2315. DOI: 10.1007/s11357-023-01000-3.
7. Guo W*, Mao X* Han D, Wang H, Zhang W, Zhang G, Zhang N, Nie B, Li H, Song Y, Wu Y#, Chang L#. Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging. Aging Brain. 2023;4:100091. DOI: 10.1016/j.nbas.2023.100091.
8. Song Y*, Du Z*, Chen X, Zhang W, Zhang G, Li H, Chang L#, Wu Y#. Astrocytic N-Methyl-D-Aspartate Receptors Protect the Hippocampal Neurons Against Amyloid-β142-Induced Synaptotoxicity by Regulating Nerve Growth Factor. J Alzheimers Dis. 2022;85(1):167-178. DOI: 10.3233/JAD-210730.
9. Zhang W, Chen X, Du Z, Mao X, Gao R, Chen Z, Wang H, Zhang G, Zhang N, Li H, Song Y, Chang L#, Wu Y#. Knockdown of astrocytic Grin2a exacerbated sleep deprivation-induced cognitive impairments and elevation of amyloid-beta. Sleep Med. 2022;100:280-290. DOI: 10.1016/j.sleep.2022.08.021.
10. Du Z*, Song Y*, Chen X, Zhang W, Zhang G, Li H, Chang L#, Wu Y#. Knockdown of astrocytic Grin2a aggravates β-amyloid-induced memory and cognitive deficits through regulating nerve growth factor. Aging Cell. 2021;20(8):e13437. DOI: 10.1111/acel.13437.
Email：changlirong@ccmu.edu.cn
010-83950489 (lab)
Address：No.10, Xitoutiao, You’anmenwai, Beijing
Research Area：Our team focuses on exploring the related molecular mechanisms of Alzheimer’s Disease and sleep disorders.