Department of Medical Genetics and Developmental Biology

Meng Guo

Associate Professor/Master’s Supervisor | Department：Department of Medical Genetics and Developmental Biology

Email：guomebg@ccmu.edu.cn

010-83950428 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：Development and characterization of animal models for diabetes and heart failure, and investigation of underlying mechanisms.

Education
2006-2012: Ph.D. in Physiology, College of Biological Sciences, China Agricultural University, China
2002-2006: B.S. in Biology, College of Biological Sciences, China Agricultural University, China

Work Experience
2020-present: Associate Professor, School of Basic Medical Sciences, Capital Medical University, China
2012-2019: Lecturer, School of Basic Medical Sciences, Capital Medical University, China

*：Co-first author; #：Co-corresponding author

1.Xiulin Zhang, Yang He, Xiaolu Zhang, Bo Fu, Zidai Song, Liang Wang, Rui Fu, Xuancheng Lu, Jin Xing, Jianyi Lv, Meng Guo, Xueyun Huo, Xin Liu, Jing Lu, Xiaoyan Du, Zhongming Ge, Zhenwen Chen, Changlong Li. Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6. Gastric Cancer. 2024 27(2):324-342.

2.Yang He, Xiulin Zhang, Xiaolu Zhang, Bo Fu, Jin Xing, Rui Fu, Jianyi Lv, Meng Guo, Xueyun Huo, Xin Liu, Jing Lu, Lixue Cao, Xiaoyan Du, Zhongming Ge, Zhenwen Chen, Xuancheng Lu, Changlong Li. Hypoxia exacerbates the malignant transformation of gastric epithelial cells induced by long-term H. pylori infection. Microbiol. Spectr. 2024 12(8):e0031124.

3.Shuxin Li, Jianyi Lv, Zhihui Li, Qiuyu Zhang, Jing Lu, Xueyun Huo, Meng Guo, Xin Liu, Changlong Li, Jinghui Wang, Hanping Shi, Li Deng, Zhenwen Chen, Xiaoyan Du. Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway. Molecular Cancer, 2024, 23(1):243.

4.Yan Wang, Peikun Zhao, Zidai Song, Xiaoyan Du, Xueyun Huo, Jing Lu, Xin Liu, Jianyi Lv, Changlong Li^#, Meng Guo^#, Zhenwen Chen. Generation of Gene-Knockout Mongolian Gerbils via CRISPR/Cas9 System, Front. Bioeng. Biotechnol., 2020, 8:780.

5.Peikun Zhao, Zidai Song, Yan Wang, Han Cai, Xiaoyan Du, Changlong Li, Jianyi Lv, Xin Liu, Meng Guo^#, Zhenwen Che^#. The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles, Aging-US, 2020, 13(1):1096-1119.

6.Meng Guo, Yuna Li, Yan Wang, Xiaohong Li, Peikun Zhao, Changlong Li, Jianyi Lv, Xin Liu, Xiaoyan Du, Zhenwen Chen Translation elongation factor eEF1A2 impairs insulin action in insulin-resistant skeletal muscle via PKC β & ER stress. J. Endocrinol., 2020, 244: 25-40.

7.Meng Guo, Cheng Zhang, Yan Wang, Lizhao Feng, Zhengpin Wang, Wanbo Niu, Xiaoyan Du, Wang Tang, Yuna Li, Chao Wang, Zhenwen Chen. Progesterone receptor membrane component 1 mediates progesterone-induced suppression of oocyte meiotic prophase I and primordial folliculogenesis. Sci. Rep. 2016 6, 36869.

8.Meng Guo, Hua Zhang, Fenghua Bian, Ge Li, Xinyi Mu, Guoliang Xia, Meijia Zhang. Progesterone down-regulates the expression of Jagged2 and Notch1. Front Biosci. 2012 6(4):2731-44.

9.Hongjuan Fang, Xiaohong Li, Jianyi Lv, Xueyun Huo, Meng Guo, Xin Liu, Changlong Li, Zhenwen Chen, Xiaoyan Du. Adipocytokines and Inflammation in Patients and a Gerbil Model: Implications for Obesity-Related and Nonobese Diabetes. Journal of Diabetes Research, 2024:9683512

10.Yafang Guo, Yutong Cui, Minghe Sun, Xiao Zhu, Yilang Zhang, Jing Lu, Changlong Li, Jianyi Lv, Meng Guo, Xin Liu, Zhenwen Chen, Xiaoyan Du, Xueyun Huo. stablishment and Application of a Novel Genetic Detection Panel for SNPs in Mongolian Gerbils. Genes, 2024, 15(8):817.