Department of Physiology and Pathophysiology

Lifei Zheng

Associate Professor/master supervisor | Department： Department of Physiology and Pathophysiology

Email：13581582937@163.com

010-83950494 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：The Zheng laboratory studies gastrointestinal Physiology and Pathophysiology, focuses on the role of brain-gut axis and brain-gut dopamine in gastrointestinal dysmotility and abnormal mucosal secretion, studies their working mechanism in gastrointestinal disorder related to Parkinson's disease and Helicobacter pylori infection.

Education
2006-2012: Ph.D. in Physiology, Department of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, China
201002-201005: Visiting Ph.D. student, department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany
2001-2006: M.D. in Clinical Medicine, Chengde Medical College, China

Work Experience
2018-present: Associate Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
2012-2018: Lecturer, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China

*：Co-first author; #：Co-corresponding author

1. Shen QY, Zhou YY, Wang YL, Qi Y, Lian DB, Li ZH, Chen MF, Zhang XL, Zhang Y, Song J, Zheng LF#, Zhu JX#. Blocking dopamine receptor 2 decreases gastrin levels in H. pylori-infected mice through increasing gastric somatostatin content. American Journal of Physiology-Cell Physiology. 2025, 328(5), C1409-C1422. DOI: 10.1152/ajpcell.00993.2024.

2. Li Z*, Wang L*, Tian C*, Wang Z, Zhao H, Qi Y, Chen W, Wuyun Q, Amin B, Lian D, Zhu J, Zhang N#, Zheng L#, Xu G#. Identification of hub biomarkers in liver post-metabolic and bariatric surgery using comprehensive machine learning (experimental studies). International Journal of Surgery, 2025, 111(2), 1814-1824. DOI: 10.1097/JS9.0000000000002179.

3. Fan YY*, Zhang Y*, Fan RF, Wang T, Yu X, Zheng LF#, Zhu JX. Impaired Nitrergic Relaxation in Pyloric Sphincter of the 6-OHDA Parkinson's Disease Rat. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2022, 322(6), G553-G560. DOI: 10.1152/ajpgi.00363.2021.

4. Liu XY*, Zheng LF#, Fan YY, Shen QY, Qi Y, Li GW, Sun Q, Zhang Y, Feng XY, Zhu JX#. Activation of dopamine D2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa. American Journal of Physiology-Cell Physiology. 2022, 322(3), C327-C337. DOI: 10.1152/ajpcell.00385.2021.

5. Zheng LF*#, Liu S, Zhou L, Zhang XL, Yu X, Zhu JX. Dopamine and Gastrointestinal Motility. In: Zhu JX. (eds) Dopamine in the Gut. Springer Singapore. 2021, 133-202. DOI: https://doi.org/10.1007/978-981-33-6586-5_5.

6. Xiu XL*, Zheng LF*, Liu XY, Fan YY, Zhu JX#. Gastric smooth muscle cells manifested an abnormal phenotype in Parkinson's disease rats with gastric dysmotility. Cell and Tissue Research, 2020, 381(2), 217-227. DOI: 10.1007/s00441-020-03214-9.

7. Zheng LF*, Ji T*, Guo ZH, Wang T, Xiu XL, Liu XY, Li SC, Sun L, Xue H, Zhang Y, Zhu JX. Na+-K+-2Cl- cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice. European Journal of Pharmacology, 2020, 880, 173162. DOI: 10.1016/j.ejphar.2020.173162.

8. Wang ZY*, Lian H*, Zhou L, Zhang YM, Cai QQ, Zheng LF#, Zhu JX#. Altered Expression of D1 and D2 Dopamine Receptors in Vagal Neurons Innervating the Gastric Muscularis Externa in a Parkinson's Disease Rat Model. Journal of Parkinsons Disease, 2016, 6(2), 317-23. DOI: 10.3233/JPD-160817.

9. Zheng LF, Song J, Fan RF, Chen CL, Ren QZ, Zhang XL, Feng XY, Zhang Y, Li LS#, Zhu JX#. The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta Physiologica, 2014, 211(2), 434-446. DOI: 10.1111/apha.12229.

10. Zheng LF, Wang ZY, Li XF, Song J, Hong F, Lian H, Wang Q, Feng XY, Tang YY, Zhang Y, Zhu JX. Reduced expression of choline acetyltransferase in vagal motoneurons and gastric motor dysfunction in a 6-OHDA rat model of Parkinson's disease. Brain Research, 2011, 1420, 59~ 67. DOI: 10.1016/j.brainres.2011.09.006.

Honors and Awards:

Third Prize for Young physiologist presentation of 2012 International Conference for Physiological Sciences