*：Co-first author; #：Co-corresponding author
1. Sun T*, Zhang JN*, Lan T, Shi L, Hu L, Yan L, Wei C, Hei L, Wu W, Luo Z, Liu M, Ren X, Wang Y, Lu Y, Wang P, Zhang C, Bian L, Zhao X, Yang F#, Li Q#. H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke. Cell Death Dis. 2025, 16(1):553. doi: 10.1038/s41419-025-07874-9.
2. Wei C*, Xiao Z*, Zhang Y*, Luo Z*, Liu D, Hu L, Shen D, Liu M, Shi L, Wang X, Lan T, Dai Q, Liu J, Chen W, Zhang Y, Sun Q, Wu W, Wang P, Zhang C, Hu J, Wang C#, Yang F#, Li Q#. Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke. Cell Death & Differentiation, 2024, 31(8):983-998. doi: 10.1038/s41418-024-01303-8.
3. Luo Z*, Sheng Z, Hu L, Shi L, Tian Y, Zhao X, Yang W, Xiao Z, Shen D, Wu W, Lan T, Zhao B, Wang X, Zhuang N, Zhang J-N, Wang Y, Lu Y, Wang L, Zhang C, Wang P, An J, Yang F#, Li Q#. Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis. eBioMedicine, 2024, 101:104993. doi: 10.1016/j.ebiom.2024.104993.
4. Wu W*, Luo Z*, Shen D, Lan T, Xiao Z, Liu M, Hu L, Sun T, Wang Y, Zhang J-N, Zhang C, Wang P, Lu Y, Yang F#, Li Q#. IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke. Redox Biology, 2024, 69:102982. doi: 10.1016/j.redox.2023.102982.
5. Lan T*, Hu L*, Sun T, Wang X, Xiao Z, Shen D, Wu W, Luo Z, Wei C, Wang X, Liu M, Guo Y, Wang L, Wang Y, Lu Y, Yu Y, Yang F, Zhang C#, Li Q#. H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1. Journal of Cerebral Blood Flow and Metabolism, 2023, 43(8):1365-1381. doi: 10.1177/0271678X231165653.
6. Liu J*, Shen D*, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, Ding Y, Liu M, Pang M, Gai K, Ma Y, Tian Y, Yu Y, Wang P, Guan Y, Xu M#, Yang F#, Li Q#. Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke. iScience, 2022, 25(12):105527. doi: 10.1016/j.isci.2022.105527.
7. Shen D, Wu W, Liu J, Lan T, Xiao Z, Gai K, Hu L, Luo Z, Wei C, Wang X, Lu Y, Wang Y, Zhang C, Wang P, Zuo Z, Yang F, Li Q. Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke. Cell Death & Disease, 2022, 13(3):259. doi: 10.1038/s41419-022-04712-0.
8. Xiao Z, Shen D, Lan T, Wei C, Wu W, Sun Q, Luo Z, Chen W, Zhang Y, Hu L, Zhang C, Wang Y, Lu Y, Wang P, Yang F, Li Q. Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice. Redox Biology, 2022, 50:102256. doi: 10.1016/j.redox.2022.102256.
9. Li Q*, Lan X*, Han X, Durham F, Wan J, Weiland A, Koehler RC#, Wang J. Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36. Brain Behavior and Immunity, 2021, 94:437-457. doi: 10.1016/j.bbi.2021.02.001.
10. Li Q, Han X, Lan X, Gao Y, Wan J, Durham F, Cheng T, Yang J, Wang Z, Jiang C, Ying M, Koehler RC, Stockwell BR, Wang J. Inhibition of neuronal ferroptosis protects hemorrhagic brain. JCI Insight. 2017, 2(7):e90777.
Honors and Awards:
1. 2023, Capital Frontier Academic Achievement Award, Beijing Association for Science and Technology.
2. 2023, Teaching and Education Award, Young Faculty Teaching Award, Capital Medical University.
Email： qianli@ccmu.edu.cn
010-83950515 (lab)
Address：No.10, Xitoutiao, You’anmenwai, Beijing
Research Area：The Li laboratory primarily employs hemorrhagic stroke as the disease model to investigate neuroprotection and immune regulation in central nervous system diseases, as well as their epigenetic pathogenesis.