Department of Cell Biology

Haiyan Zhang

Professor | Department：Department of Cell biology

Email：culture@ccmu.edu.cn

010-83950409 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing, China.

Research Area：The Zhang Laboratory investigates stem cell biology, with a primary focus on elucidating the regulatory mechanisms underlying hepatocyte differentiation and liver organoid development.

Education
2001-2004: Ph.D. in Neurobiology, Capital Medical University, Beijing, China.
1991-1994: M.S. in Parasitology, Capital Medical University, Beijing, China.
1984-1989: B. S. in Clinical Medicine, ShanXi Medical University, ShanXi, China
Work Experience
1994-present: Professor, Department of Cell Biology, Capital Medical University, China.
2006-2007: Postdoctoral Researcher, Karolinska Institutet at Stockholm, Sweden.
1989-1991: Resident physician, Ping Ding People's Hospital, ShanXi province, China.

*：Co-first author; #：Co-corresponding author

1.Zhang Y*, Hua M*, Ma X, Li W, Cao Y, Han X, Huang X, Zhang H. Dipeptidyl peptidase-4 marks distinct subtypes of human adipose stromal/stem cells with different hepatocyte differentiation and immunoregulatory properties. Stem Cell Res Ther. 2024 Sep 29;15(1):338. DOI: 10.1186/s13287-024-03950-7.

2.Bi G, Zhang X, Li W, Lu X, He X, Li Y, Bai R, Zhang H. Modeling alcohol-associated liver disease in humans using adipose stromal or stem cell-derived organoids. Cell Rep Methods. 2024 May 20;4(5):100778. DOI: 10.1016/j.crmeth.2024.100778.

3.Han X, Li W, He X, Lu X, Zhang Y, Li Y, Bi G, Ma X, Huang X, Bai R, Zhang H. Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue. Stem Cell Res Ther. 2023 Oct 8;14(1):291. DOI: 10.1186/s13287-023-03525-y.

4.Ma Y, Zhang W, Li W, Lu X, Li Y, Han X, Wang P, Zhang H. alpha5 integrin regulates hepatic tight junctions through SRC-TET1-mediated DNA hydroxymethylation. iScience. 2022; 25:105611. DOI: 10.1016/j.isci.2022.105611.

5.Li Y, Lin Y, Han X, Li W, Yan W, Ma Y, Lu X, Huang X, Bai R#, Zhang H#. GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients. iScience. 2021 Feb 6;24(3):102149. DOI: 10.1016/j.isci.2021.102149.

6.Ma Y, Ma M, Sun J, Li W, Li Y, Guo X, Zhang H. CHIR-99021 regulates mitochondrial remodelling via β-catenin signalling and miRNA expression during endodermal differentiation. J Cell Sci. 2019 Jul 31;132(15). pii: jcs229948. DOI: 10.1242/jcs.229948.

7.Guo X, Li W, Ma M, Lu X, Zhang H. Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signalling. J Cell Mol Med. 2017 Nov; 21(11):2809-2822. DOI: 10.1111/jcmm.13195.

8.Huang J*, Guo X*, Li W, Zhang H. Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci Rep. 2017 Jan 17; 7:40716. DOI: 10.1038/srep40716.

9.Yuan J, Li W, Huang J, Guo X, Li X, Lu X, Huang X, Zhang H. Transplantation of human adipose stem cell-derived hepatocyte-like cells with restricted localization to liver using acellular amniotic membrane. Stem Cell Res Ther. 2015 Nov 5; 6:217. DOI: 10.1186/s13287-015-0208-9.

10.Li X, Yuan J, Li W, Liu S, Hua M, Lu X, Zhang H. Direct differentiation of homogeneous human adipose stem cells into functional hepatocytes by mimicking liver embryogenesis. J Cell Physiol. 2014; 229(6):801-12. DOI: 10.1002/jcp.24501.