Department of Cell Biology

Liying Li

Professor/doctoral supervisor | Department：Department of Cell Biology

Email：liliying@ccmu.edu.cn

010-83950468 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：The Li laboratory studies Hepatology, the molecular mechanism of innate immune cells, including macrophages, monocytes, neutrophils, bone marrow mesenchymal stem cells, etc., which are involved in the process of liver injury/inflammation/fibrosis/sclerosis, as well as the mechanism of some endogenous bioactive molecules in this process.

Education
2000-2003: Ph.D. in Cell Biology, University of Paris XI, France
1992-1995: Master's Degree. in Biochemistry, Peking University, China
1981-1986: B.S. in Pharmacochemistry, Peking University, China

Work Experience
2005-present: Professor, School of Basic Medical Sciences, Capital Medical University, China
2003-2005: Associate Professor, School of Basic Medical Sciences, Peking University, China

*：Co-first author; #：Co-corresponding author

1.Chang N*, Ma Y*, Liu J, Li W, Zhao J, Liu Y, Liu F, Dong C, Liu C, Qi C, Yang L, Li L. IQGAP1 participates in bone marrow-derived macrophage recruitment and involves in liver inflammation/fibrosis. J Mol Med (Berl). 2025 Jul 19. doi: 10.1007/s00109-025-02573-6.

2.Yue W, Zhang H, Gao Y, Ding J, Xue R, Dong C, Liu F, Yang L, Yang L#, Li L#. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167205. doi: 10.1016/j.bbadis.2024.167205.

3.Chang N*, Liu Y*, Li W, Ma Y, Zhou X, Zhao X, Yang L, Li L. Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration. J Mol Med (Berl). 2024 Sep;102(9):1117-1133.

4.Li W, Yang Y, Yang L, Chang N#, Li L#. Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury. Cell Rep. 2023, 42(10): 113164.

5.Yang Y*, Li W*, Liu C, Liu J, Yang L, Yue W, Yang L, Xue R, Zhang K, Zhang H, Chang N#, Li L#. Single-cell RNA seq identifies Plg-RKT-PLG as signals inducing phenotypic transformation of scar-associated macrophage in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166754.

6.Yang S*, Chang N*, Li W*, Yang T, Xue R, Liu J, Zhang L, Yao X, Chen Y, Wang H, Yang L, Huang J#, Li L#. Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis. Cell Death Dis. 2023 Mar 1;14(3):175.

7.Lu Y, Chang N, Zhao X, Xue R, Liu J, Yang L and Li L. Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses. Front. Immunol. 2022;13:824385.

8.Yang L, Yue W, Zhang H, Zhang Z, Xue R, Dong C, Liu F, Chang N, Yang L, Li L. Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis. Hepatol Commun. 2022 Jun;6(6):1425-1442.

9.Yang J, He L, Gao M, Xiao F, Zhang F, Wang S, Shu Y, Ye X, Qu W, Li L#, Wei H#. Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. METABOLISM-CLINICAL AND EXPERIMENTAL. 2021 Jul;120:154777.

10.Zhao X, Yang L, Chang N, Hou L, Zhou X, Yang L, Li L. Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling. Cell Death Dis. 2020 May 18;11(5):379.