Department of Immunology

Xulong Zhang

Professor/doctoral supervisor | Department：Department of Immunology

Email： zhxlwl@ccmu.edu.cn

010-83950464 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：The Zhang laboratory studies immune response and immune regulation during infection, focuses on cellular and molecular mechanisms of immunopathological damage (or immune tolerance) induced by severe infection (or chronic infection), searches for therapeutic targets and explores treatment strategies in related diseases.

Education
2003-2008: Ph.D. in Microbiology and Biochemical Pharmacy, School of Life Sciences, School of Pharmacy, Shandong University, China.
1999-2003: B.S. in Biology, National Biology Talent Training Base Class, School of Life Sciences, Northeast Normal University, China.
Work Experience
2022-present: Professor and Director, Department of Immunology, School of Basic Medical Sciences, Capital Medical University, China.
2015-2021: Associate Professor and Deputy Director, Department of Immunology, School of Basic Medical Sciences, Capital Medical University, China.
2010-2014: Lecture, Department of Immunology, School of Basic Medical Sciences, Capital Medical University, China.
2008-2010: Postdoctoral in Immunology. Institute of Immunology, University of Science and Technology of China, China.

*：Co-first author; #：Co-corresponding author

1Ziqi Hu, Xu Wu, Duoduo Yao, Jianhua Liu, Qingli Kong, Yu-Jie Zhou, Xulong Zhang#. Ficolin A and ficolin B aggravate poly(I:C) secondary LPS stimulation-induced acute lung injury by modulating alveolar and interstitial macrophages. Cytokine. 2025 Apr:188:156868. doi: 10.1016/j.cyto.2025.156868.

2Weixia Xuan*, Xu Wu*#, Longcheng Zheng, Huayun Jia, Xiaoju Zhang, Xulong Zhang#, Bin Cao#. Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4. Cell Mol Life Sci. 2024 Oct 25;81(1):438. doi: 10.1007/s00018-024-05474-y.

3Yang Wang*, Qingli Kong*, Qi Zhang, Tianxiao Ma, Yunqing An, Yu-jie Zhou, Xulong Zhang#, Bin Cao#. BPI₂₃-Fcγ alleviates lethal multidrug-resistant Acinetobacter baumannii infection by enhancing bactericidal activity and orchestrating neutrophil function. International Journal of Antimicrobial Agents 2024 Jan;63(1):107002. doi: 10.1016/j.ijantimicag.2023.107002.

4Duoduo Yao, Linlin Bao, Fengdi Li, Bo Liu, Xu Wu, Ziqi Hu, Jiangnan Xu, Wei Wang# Xulong Zhang^#. H1N1 influenza virus dose dependent induction of dysregulated innate immune responses and STAT1/3 activation are associated with pulmonary immunopathological damage. Virulence. 2022 Sep; 13:1, 1558-1572. DOI: 10.1080/21505594.2022.2120951

5Xu Wu*, Linlin Bao*, Ziqi Hu, Duoduo Yao, Fengdi Li, Hui Li, Xiaoxue Xu, Yunqing An, Xi Wang, Bin Cao#, Xulong Zhang# Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation. Cell Mol Immunol. 2021 Sep;18(9):2278-2280. doi: 10.1038/s41423-021-00737-1

6Xu Wu, Duoduo Yao, Linlin Bao, Di Liu, Xiaoxue Xu, Yunqing An, Xulong Zhang#, Bin Cao#. Ficolin A derived from local macrophages and neutrophils protects against lipopolysaccharide-induced acute lung injury by activating complement. Immunol Cell Biol. 2020 Aug;98(7):595-606.

7Xuehong Jia, Bin Cao, Yunqing An, Xulong Zhang#, Chen Wang#. Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production. International Immunopharmacology. 2019 Feb;67:211-219.

8Xuehong Jia, Bo Liu, Linlin Bao, Qi Lv, Fengdi Li, Hui Li, Yunqing An, Xulong Zhang#, Bin Cao#, Chen Wang#. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathogens. 2018;14(11): e1007428.

9Xue Chunxue, Wen Mingjie, Bao Linlin, Li Hui, Li Fengdi, Liu Meng, Lv Qi, An Yunqing, Zhang Xulong#, Cao Bin#. Vγ4+γδT Cells Aggravate Severe H1N1 Influenza Virus Infection-Induced Acute Pulmonary Immunopathological Injury via Secreting Interleukin-17A. Frontiers in immunology. 2017 Aug 31;8:1054.

10Bo Liu*, Xulong Zhang*, Wei Deng*, Jun Liu, Hui Li, Mingjie Wen, Linlin Bao, Jiuxin Qu, Yingmei Liu, Fengdi Li, Yunqing An, Chuan Qin, Bin Cao#, Chen Wang#. Severe Influenza A(H1N1)pdm09 Infection Induces Thymic Atrophy Through Activating Innate CD8+ CD44hi T Cells by Up-regulating IFN-γ. Cell Death & Disease. 2014 Oct 2;5:e1440.

Honors and Awards:

1.Teaching Award of Capital Medical University, 2024.

2.Beijing Higher Education High Quality Undergraduate Textbook Courseware, 2020.

3.Youth Teaching Award of Capital Medical University, 2019.

4.Second Prize in the 9^th National Basic Teaching Skills Competition for Young Teachers in Medical (Pharmaceutical) Colleges.

5.Third Prize in the Medical Category of the 11^th Beijing Young Teachers' Teaching Basic Skills Competition.

6.First Prize in the 11^th Teaching Competition for Young Teachers at the School of Basic Medicine, Capital Medical University.