Department of Neurobiology

Fei Yang

Professor/doctoral supervisor | Department：Department of Neurobiology

Email：feiyang@ccmu.edu.cn

010-83950415 (lab)

Address： No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：Chronic pain mechanisms—peripheral and central pathways—using pre-clinical pain models.

Education
2006-2009: Ph.D., Neuroscience Institute, Peking University, China
2001-2006: B.S., 8-Year Basic Medical Science Program, Peking University, China

Work Experience
2018-present: Chair, Professor & Doctoral Supervisor, Department of Neurobiology, Capital Medical University , Beijing, China
2018-present: Professor & Doctoral Supervisor, Department of Neurobiology, Capital Medical University, Beijing, China
2016-2018: Research Associate, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, USA
2010-2016: Postdoctoral Fellow, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, USA

*：Co-first author; #：Co-corresponding author

1.Chao Wei*, Zhongnan Xiao*, Yanling Zhang*, Zhaoli Luo*, Dongyang Liu, Liye Hu, Danmin Shen, Meng Liu, Lei Shi, Xiaotong Wang, Ting Lan, Qingqing Dai, Jing Liu, Wen Chen, Yurui Zhang, Qingyu Sun, Weihua Wu, Peipei Wang, Chenguang Zhang, Junchi Hu, Chu Wang#, Fei Yang#, Qian Li#. Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke. Cell Death & Differentiation , 2024 May 8. doi: 10.1038/s41418-024-01303-8.

2.Zhaoli Luo, Ziyang Sheng, Liye Hu, Lei Shi, Yichen Tian, Xiaochu Zhao, Wei Yang, Zhongnan Xiao, Danmin Shen, Weihua Wu, Ting Lan, Boqian Zhao, Xiaogang Wang 3, Nan Zhuang, Jian-Nan Zhang, Yamei Wang, Yabin Lu, Liyong Wang, Chenguang Zhang, Peipei Wang, Jing An, Fei Yang#, Qian Li#. Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis. eBioMedicine , 2024 Mar:101:104993. doi: 10.1016/j.ebiom.2024.104993.

3.Weihua Wu*, Zhaoli Luo*, Danmin Shen, Ting Lan, Zhongnan Xiao, Meng Liu, Liye Hu, Tingting Sun, Yamei Wang, Jian-Nan Zhang, Chenguang Zhang, Peipei Wang, Yabin Lu 1, Fei Yang#, Qian Li#. IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke. Redox Biology , 2024 Feb:69:102982. doi: 10.1016/j.redox.2023.102982.

4.Yichen Zhou*, Miaoyi Pang, Yiran Ma, Lingling Lu, Jiannan Zhang, Peipei Wang, Qian Li, Fei Yang. Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine. Molecular Neurobiology , 2024 Feb;61(2):1202-1220. doi: 10.1007/s12035-023-03623-1.

5.Chen W^*, Wang X^*, Sun Q, Zhang Y, Liu J, Hu T, Wu W, Wei C, Liu M, Ding Y, Liu D, Chong Y, Wang P, Zhu H, Cui W, Li Q#, Yang F#. The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice. Journal of Neuroinflammation , 2022, 19(1):302.

6.Liu J^*, Shen D^*, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, Ding Y, Liu M, Pang M, Gai K, Ma Y, Tian Y, Yu Y, Wang P, Guan Y, Xu M#, Yang F#, Li Q#. Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke. iScience , 2022, 25(12):105527.

7.Sun Q^*, Hu T^*, Zhang Y, Wang X, Liu J, Chen W, Wei C, Liu D, Wu W, Lan T, Ding Y, Luo Z, Liu M, Shen D, Xiao Z, Hu L, Pang M, Ma Y, Shi L, Wang P, Zhang J, Li Q#, Yang F#. IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury. Frontiers in Immunology , 2022, 13:1012442.

8.Ding Y^*, Hu L^*, Wang X, Sun Q, Hu T, Liu J, Shen D, Zhang Y, Chen W, Wei C, Liu M, Wang P, Zhang C, Zhang J, Li Q#, Yang F#. The Contribution of Spinal Dorsal Horn Astrocytes in Neuropathic Pain at the Early Stage of EAE. Neurobiology of Disease , 2022, 185: 105914. doi: 10.1016/j.nbd.2022.105914.PMID: 36332813.

9.Tingting Hu, Qingyu Sun, Yu Gou, Yurui Zhang, Yumeng Ding, Yiran Ma, Jing Liu, Wen Chen, Ting Lan, Peipei Wang, Qian Li, Fei Yang. Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway. Neurochemical Research . 2022. 47(2):493-502.