*:Co-first author; #:Co-corresponding author
1.Zou W*, Deng S*, Chen X*, Ruan J*, Wang H, Zhan W, Wang J, Liu Z, Yan Z#. TMEM63B functions as a mammalian hyperosmolar sensor for thirst, Neuron, 2025, 113, 1430-1445. DOI: 10.1016/j.neuron.2025.02.012
2.Fu S*, Pan X*, Lu M*, Dong J, Yan Z#. Human TMC1 and TMC2 are mechanically gated ion channels. Neuron, 2025, 113(3), 411–425.e4. DOI: 10.1016/j. neuron. 2024.11.009
3. Zheng H*, Yan X*, Li G, Lin H, Deng S, Zhuang W, Yao F, Lu Y, Xia X, Yuan H, Jin L, Yan Z#. Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4. Genome Research, 2022, 32: 1573-1584. DOI: 10.7554/eLife.58388
4. Li S, Li B, Gao L, Wang J, Yan Z#. Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63. Nature Communications, 2022, 13: 3814. DOI: 10.1038/s41467-022-31253-z
5.Li B*, Li S*, Zheng H, Yan Z#. Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118: e2106459118. DOI: 10.1073/pnas.2106459118
6.Wang Y*, Guo Y*, Li G, Liu C, Wang L, Zhang A, Yan Z#, Song C#. The push-to-open mechanism of the tethered mechanosensitive ion channel NompC. eLife, 2021, 10: e58388. DOI: 10.7554/eLife.58388
7.Jia Y*, Zhao Y*, Kusakizako T*, Wang Y, Pan C, Zhang Y, Nureki O#, Hattori M#, Yan Z#. TMC1 and TMC2 proteins are pore-forming subunits of mechanosensitive ion channels. Neuron, 2020, 105: 310–321. DOI: 10.1016/j.neuron.2019.10.017
8.Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z#, Song C#, Chen L#. Structure of the mechanosensitive OSCA channels. Nature Structural & Molecular Biology, 2018, 25: 850–858. DOI: 10.1038/s41594-018-0117-6
9.Zhang M*, Li X*, Zheng H, Wen X, Chen S, Ye J, Tang S, Yao F, Li Y#, Yan Z#. Brv1 is required for Drosophila larvae to sense gentle touch. Cell Reports, 2018, 23: 23-31. DOI: 10.1016/j.celrep.2018.03.041
Honors and Awards:
2014
The Shanghai Rising-Star Program
2014
The Program for Professor of Special Appointment (Eastern Scholar of Shanghai)
2010 - 2013
Human Frontier Science Program (HFSP) Long-term Fellowship