*：Co-first author; #：Co-corresponding author
1.Guo B*, Song H*, Fan J, Wang B, Chen L, Hu Q, Yin Y. The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults. Experimental Brain Research. 2023, 241, 2735-2750. DOI: 10.1007/s00221-023-06710-w
2.Wan R, Fan J, Song H, Sun W#, Yin Y#. Oxygen-Glucose Deprivation/Reperfusion-Induced Sirt3 Reduction Facilitated Neuronal Injuries in an Apoptosis-Dependent Manner During Prolonged Reperfusion. Neurochemical Research. 2022, 47, 1012-1024. DOI: 10.1007/s11064-021-03502-y
3.Zhang X*, Wei M*, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y#, Wang W#. Ischemia-induced Upregulation of Autophagy Preludes Dysfunctional Lysosomal Storage and Associated Synaptic Impairments in Neurons. Autophagy. 2021, 17, 1519-1542. DOI: 10.1080/15548627.2020.1840796
4.Yan W, Fan J, Zhang X, Song H, Wan R, Wang W#, Yin Y#. Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance. Theranostics. 2021, 11, 4616-4636. DOI: 10.7150/thno.54210
5.Yan W*, Sun W*, Fan J, Wang H, Han S, Li J, Yin Y. Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice. Neuroscience Bulletin. 2020, 36, 845-859. DOI: 10.1007/s12264-020-00489-4
6.Diao Y*, Yan W*, Sun W, Luo Y, Li J, Yin Y. The dual role of KCNQ/M channels upon OGD or OGD/R insults in cultured cortical neurons of mice: Timing is crucial in targeting M-channels against ischemic injuries. Journal of Cellular Physiology. 2019, 234, 12714-12726. DOI: 10.1002/jcp.27889
7.Li Y, Sun W, Han S, Li J, Ding S, Wang W, Yin Y. IGF-1-involved negative feedback of NR2B NMDA subunits protects cultured hippocampal neurons against NMDA-induced excitotoxicity. Molecular Neurobiology. 2017, 54, 684-696. DOI: 10.1007/s12035-015-9647-7
8.Yin Y*#, Zhao Y, Han S, Zhang N, Chen H, Wang X#. Autophagy-ERK1/2-involved Disinhibition of Hippocampal Neurons Contributes to the Pre-synaptic Toxicity Induced by Aβ42 Exposure. Journal of Alzheimer's Disease. 2017, 59, 851-869. DOI: 10.3233/JAD-170246
9.Diao Y, Tian Y, Han S, Zhang N, Li J, Yin Y. Current insight into the role of voltage-gated potassium ion channel 7 (Kv7) channels: an emerging therapy target against epilepsy. Neuropsychiatry. 2016, 6, 420-425.
10.Yin Y#, Han Z, Huang P, Wei G, Zhou C, Wen J, Su B, Wang X#, Wang Y#. Collagen nanofibers facilitated pre-synaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through MAPK/ERK1/2-Synapsin I signaling pathway. Biomacromolecules. 2014, 15, 2449-2460. DOI: 10.1021/bm500321h
Honors and Awards:
Natural Science Award (Second Class), Capital Medical University, 2021: Mechanisms of Synaptic Dysfunction in Acute Ischemic Stroke
Email：yylin@ccmu.edu.cn
010-83950394 (lab)
Address：No.10, Xitoutiao, You’anmenwai, Beijing
Research Area： The prevention and treatment strategies against post-stroke cognitive impairment; The role of autophagy in cerebral ischemic-reperfusion injury and the pathogenesis of post-stroke cognitive impairmen.