Department of Pathogen Biology

Peigang Wang

Professor/doctoral supervisor | Department：Department of Pathogen Biology

Email：pgwang@ccmu.edu.cn

010-83951688 (lab)

Address：No.10, Xitoutiao, You’anmenwai, Beijing

Research Area：Vector-borne viruses, Viral-host interaction.

Education
2005 to 2013: Postdoctoral Fellow, HKU-Pasteur Research Center, The University of Hong Kong
2000 to 2004: PhD candidate, the College of Life Science, Peking University

Work Experience
2024 to Present: Professor, Director, Department of Microbiology, Capital Medical University
2016 to 2023: Associate Professor, Department of Microbiology, Capital Medical University
2013 to 2015: Associate Professor, Institute of Biophysics, Chinese Academy of Science

*：Co-first author; #：Co-corresponding author

1)Yang, W.*, Liu, L. B.*, Liu, F. L.*, Wu, Y. H.*, Zhen, Z. D., Fan, D. Y., Sheng, Z. Y., Song, Z. R., Chang, J. T., Zheng, Y. T.#, An, J.#, Wang, P. G.# Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation. Nature communications 14, 2476, (2023).

2)Liu, L. B., Yang, W., Chang, J. T., Fan, D. Y., Wu, Y. H., Wang, P. G.#, An, J.# Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice. Journal of virology 97, (2023).

3)Sheng, Z. Y.*, Li, M.*, Yang, R., Liu, Y. H., Yin, X. X., Mao, J. R., Brown, H. E., An, J.#, Zhou, H. N.#, Wang, P. G.# COVID-19 prevention measures reduce dengue spread in Yunnan Province, China, but do not reduce established outbreak. Emerging microbes & infections 11, 240-249, (2022).

4)Wang, Y. S.*, Liu, D.*, Wang, X.*, Luo, Q. L., Ding, L., Fan, D. Y., Cai, Q. L., Tang, C. Y., Yang, W., Guan, Y. G., Li, T. F., Wang, P. G.#, Luan, G. M.#, An, J.# Rasmussen's encephalitis is characterized by relatively lower production of IFN-beta and activated cytotoxic T cell upon herpes viruses infection. Journal of neuroinflammation 19, 70, (2022).

5)Wang, Z. Y., Zhen, Z. D., Fan, D. Y., Qin, C. F., Han, D. S., Zhou, H. N., Wang, P. G.#, An, J.# Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1alpha Production from Pyroptotic Macrophages. Journal of virology 94, (2020).

6)Wang, P. G., Tang, D. J., Hua, Z., Wang, Z.#, An, J.# Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation. Cell discovery 6, 71, (2020).

7)Yang, W., Wu, Y. H., Liu, S. Q., Sheng, Z. Y., Zhen, Z. D., Gao, R. Q., Cui, X. Y., Fan, D. Y., Qin, Z. H., Zheng, A. H., Wang, P. G.#, An, J.# S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation. PLoS pathogens 16, e1009019, (2020).

8)Wu, Y. H.*, Cui, X. Y.*, Yang, W., Fan, D. Y., Liu, D., Wang, P. G.#, An, J.# Zika Virus Infection in Hypothalamus Causes Hormone Deficiencies and Leads to Irreversible Growth Delay and Memory Impairment in Mice. Cell reports 25, 1537-1547 e1534, (2018).

9)Li, M. Y., Grandadam, M., Kwok, K., Lagache, T., Siu, Y. L., Zhang, J. S., Sayteng, K., Kudelko, M., Qin, C. F., Olivo-Marin, J. C., Bruzzone, R.#, Wang, P. G.# KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum. Cell reports 10, 1496-1507, (2015).

10)Kudelko, M., Brault, J. B., Kwok, K., Li, M. Y., Pardigon, N., Peiris, J. S. M., Bruzzone, R., Despres, P., Nal, B.#, Wang, P. G.# Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. The Journal of biological chemistry 287, 767-777, (2012).