*:Co-first author; #:Co-corresponding author
1. Xie Q; Chu Y; Yuan W; Li Y; Li K; Wu X; Liu X; Xu R; Cui S#; Qu X#. Activation of insulin like growth factor-1 receptor (IGF-1R) promotes growth of colorectal cancer through triggering the MEX3A-mediated degradation of RIG-I, Acta Pharm Sin B 2023;13:2963-2975.
2. Guo ZK; Wu XF; Tan MY; Liang WS; Yang YM; Chu ZZ; Xu R; Li KQ; Cheng YY; Zhang YZ; Zhang YH; Hai Y#; Cui SX#; Qu XJ#. Activation of sphingosine-1-phosphate receptor 2 (S1PR2) upregulates dihydropyrimidine dehydrogenase (DPD) expression in colon cancer cells, J Adv Res 2025; S2090-1232(25): 00025-6
3. Li Yanan; Li Keqin; Pan Ting; Xie Qiaobo; Cheng Yuyao; Wu Xinfeng; Xu Rui; Liu Xiaohui; Liu Li; Gao Jiangming; Yuan Wenmin; Qu Xianjun#; Cui Shuxiang#. Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca(2+) ER perturbation in hepatocellular carcinoma, Acta Pharmaceutica Sinica B 2023;13: 3744-3755
4. Rong-Rong Miao; Ming-Yong Tan; Han-Bing Shao; Zhi-Meng Sun; Sheng Zhan; Wei-Shi Liang; Xiao-Hui Liu; Ke-Qin Li; Yu-Yao Cheng; Xin-Feng Wu; Rui Xu; Shu-Xiang Cui; Yong Hai#; Xian-Jun Qu#. Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisomeproliferator-activated receptor alpha, Cell Communication and Signaling 2025, 23: 240.
5. Dongdong Luo; Xiaochun Liu; Leilei Jiang; Zhikun Guo; Yan Lv; Xiaochen Tian; Xiaoyan Wang; Shuxiang Cui; Shengbiao Wan; Ximing Xu#; Xiaoyang Li#; Xianjun Qu#; Rational Design, synthesis, and biological evaluation of novel S1PR2 antagonists for reversing 5-FU-resistance in colorectal cancer. J Med Chem 2022;65:14553-14577.
6. Si-Yuan Mu, Rui Xu, Xin-Feng Wu, Yu-Yao Cheng, Zhi-Meng Sun, Han-Tao Liu, Han-Bing Shao, Xiao-Nan Zhang, Xi-Nan Zhang, Ming Yang, Ming-Yong Tan, Wei-Shi Liang, Sheng-Biao Wan, Shu-Xiang Cui, Xian-Jun Qu. Inhibition of sphingosine-1-phosphate receptor-2 attenuates idiopathic pulmonary fibrosis by preventing its binding to dapper1 in bronchial epithelial cells. Br J Pharmacol. 2025. doi: 10.1111/bph.70043.
7. Yu-Hang Zhang, Wen-Na Shi, Shu-Hua Wu, Rong-Rong Miao, Shi-Yue Sun, Dong-Dong Luo, Sheng-Biao Wan, Zhi-Kun Guo, Wen-Yu Wang, Xin-Feng Yu, Shu-Xiang Cui#, Xian-Jun Qu#. SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression. Oncogene 2020;39:5214-5227.
8. Shi-Yue Sun, Xue-Tao Hu, Xin-Feng Yu, Yue-Ying Zhang, Xiao-Hui Liu, Yuan-Hang Liu, Shu-Hua Wu, Yang-Yang Li, Shu-Xiang Cui#, Xian-Jun Qu#. Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer. Br J Pharmacol. 2021;178:2351-2369.
9. Song ZY, Wang F, Cui SX, Gao ZH#, Qu XJ#. CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis. Oncogene 2019;38:1560-1575.
10. Zhang YH, Luo DD, Wan SB, Qu XJ. S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer. Pharmacol Res. 2020;155:104717.