*：Co-first author; #：Co-corresponding author
1.Yanru Duan*, Demin Liu*, Huahui Yu, Shihan Zhang, Yihua Xia, Zhiyong Du, Yanwen Qin, Yajing Wang, Xinliang Ma, Huirong Liu# and Yunhui Du#. Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes. Cell & Bioscience. 2024, 14(1):126. doi: 10.1186/s13578-024-01306-5.
2.Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxve Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du#, Huirong Liu#. Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects, iScience, 2023, 26(4):106428. doi: 10.1016/j.isci.2023.106428.
3.Xi Zhang, Bingjie Li, Yingshuo Yan, Fei Sun, Suli Zhang, Meili Wang#, Huirong Liu#. AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2. Biochemical Pharmacology. 2023, 11:115977. doi: 10.1016/j.bcp.2023.115977.
4.Yang Li, Yuan Tian, Shu Shi, Xiaohong Hou, Haihu Hao, Mingxia Ma, Na Ning, Yuan Yuan, Xiaohui Wang, Huirong Liu#, Li Wang#. Epac1 participates in β1-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2023, 1870(7):119512. doi: 10.1016/j.bbamcr.2023.119512.
5.Meili Wang, Xiaochen Yin, Shuanglei Li, Xi Zhang, Ming Yi, Chunyu He, Xiaoyue Li, Wei Wang, Suli Zhang#, Huirong Liu#. Large‐Conductance Calcium‐Activated Potassium Channel Opener, NS1619, Protects Against Mesenteric Artery Remodeling Induced by Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor. Journal of the American Heart Association. 2022, 11:e024046. doi: 10.1161/JAHA.121.024046.
6.Hao Chen*, Ning Cao*, Li Wang, Ye Wu, Haojie Wei, Yuming Li, Youyi Zhang, Suli Zhang# and Huirong Liu#. Biased activation of β2-AR/Gi/GRK2 signal pathway attenuated β1-AR sustained activation induced by β1-adrenergic receptor autoantibody. Cell Death Discovery. 2021 Nov 8;7(1):340. doi: 10.1038/s41420-021-00735-2.
7.Yan Sun, Yang Li, Meili Wang, Mingming Yue, Lina Bai, Jingwei Bian, Weiwei Hao, Jing Sun, Suli Zhang#, Huirong Liu#. Increased AT2R Expression Is Induced by AT1R Autoantibody via Two Axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to Promote VSMC Migration. Cell Death & Disease. 2020, 11(6):432. doi: 10.1038/s41419-020-2643-5.
8.Xu Wenli, Wu Ye, Wang Li, Bai Yan, Du Yunhui, Li Yang, Cao Ning, Zhao Yuhui, Zhang Youyi, Huirong Liu#. Autoantibody against beta1-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4+ T cells by up-regulating AMPK-mediated fatty acid oxidation. Cell death & disease. 2019, 10(3):158. doi: 10.1038/s41419-018-1209-2.
9. Ning Cao, Hao Chen, Yan Bai, Xiaochun Yang, Wenli Xu, Weiwei Hao, Yi Zhou, Jiayin Chai, Ye Wu, Zhaojia Wang, Xiaochen Yi, Linguo Wu, Wen Wang#, Huirong Liu#, Michael L.X. Fu. β2-adrenergic receptor autoantibodies alleviate myocardial damage induced by β1-adrenergic receptor autoantibodies in heart failure. Cardiovascular Research. 2018, 114(11):1487-1498. doi: 10.1093/cvr/cvy105.
10.Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL#. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005, 111(1):90-6. doi: 10.1161/01.CIR.0000151613.90994.17.
Honors and Awards:
2024: Beijing Municipal Worker Pioneer Team
2023: The Capital's Labor Medal
2019: Huaxia Medical Science and Technology Award
2019: National Advanced Collective in Education System
2018: National Huang Danian-Style Teacher Team in Higher Education
2016: The 12th Beijing Municipal Teaching Excellence Award for Higher Education Institutions
Email： liuhr2000@126.com
010-83950505 (lab)
Address：No.10, Xitoutiao, You’anmenwai, Beijing
Research Area：The Liu laboratory investigates GPCR autoantibodies, with a primary focus on elucidating the role of cardiac G protein-coupled receptor autoantibodies in the pathogenesis of cardiovascular diseases.